SetmEegenin 1
StemRegenin 1
CAS: 1227633-49-9
Molecular Formula: C24H23N5OS
SetmEegenin 1 - Names and Identifiers
SetmEegenin 1 - Physico-chemical Properties
| Molecular Formula | C24H23N5OS |
| Molar Mass | 429.54 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Boling Point | 604.9±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 33 mg/mL |
| Appearance | White solid |
| Color | Off-white |
| pKa | 10.03±0.15(Predicted) |
| Storage Condition | +2C to +8C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | StemRegenin 1 treatment increased the number of CD34 cells with an EC50 of 120 nM after 5 to 7 days. Compared with the control group, mPB CD34 cells cultured with cytokines and SR1 (1 μm) for 7 days can increase the number of CD34 , CD133 and CD90 hematopoietic stem cells and progenitor cells by 2.6 times, respectively, 2.3 times and 10 times. Continuous culture with SR1 (1 μm) for 3 weeks resulted in an 11-fold increase in the total number of nucleated cells, a 73-fold increase in the number of CD34 cells, and a 1118-fold increase in the number of CD34 cells compared to controls. Treatment with SR1 (1 μm) cultured 1 × 10 SR1 (1 μm) could accelerate the proliferation of CD34 cells and reduce the expression level of VentX in human CD34 cells. Ectopic expression of VentX prevents sr1-induced CD34 cell enlargement. Continuous co-culture of bone morphogenetic protein 4 (20 ng/mL) with PGE2 (2 μm) and SR1 (0.75 μm) resulted in the formation of robust rhesus monkey induced pluripotent hematopoietic progenitors. CD34( )CD38(-)Thy1( )CD45RA(-)CD49f() cells were isolated based on CD34 expression and cultured in cells containing SR1 (0.75 μm) the number was expanded 3-fold in the culture medium and this long-term replanted hematopoietic stem cell phenotype was maintained. |
| In vivo study | SR1 promotes the expansion of cbcd34 cells, which contributes to the early and sustained transplantation of NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice. |
SetmEegenin 1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
SetmEegenin 1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.328 ml | 11.64 ml | 23.281 ml |
| 5 mM | 0.466 ml | 2.328 ml | 4.656 ml |
| 10 mM | 0.233 ml | 1.164 ml | 2.328 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.466 ml |
Last Update：2024-01-02 23:10:35
SetmEegenin 1 - Reference Information
| biological activity | StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor, the IC50 in the cell-free assay was 127 nM. |
| Target | Value |
| Aryl hydrocarbon receptor (AhR) (Cell-free assay) | 127 nM |
Last Update：2024-04-09 21:04:16
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Multiple SpecificationsSpot supply
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tech@medchemexpress.com
Mobile: 609-228-6898
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Mobile: +86-18621343501
QQ: 2881950922
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View History
SetmEegenin 1
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阿达帕林杂质C USP标准品
4-甲氧基-3,5-二甲基吡啶1-氧化物(奥美拉唑杂质)
(4-Chloro-1-methyl-1h-pyrazol-5-yl)methanamine dihydrochloride
假荜茇酰胺B
盐酸喹那普利相关物质
聚(2-乙基己基丙烯酸酯)
叔丁基 1-氧杂-4,8-二氮杂螺[5.5]十一烷-4-甲酸酯
NH2-PEG-Tert(叔丁酯)
α-Methyl-1-pyreneMethanol
阿达帕林杂质C USP标准品
4-甲氧基-3,5-二甲基吡啶1-氧化物(奥美拉唑杂质)
(4-Chloro-1-methyl-1h-pyrazol-5-yl)methanamine dihydrochloride
假荜茇酰胺B